Connect the dots: exposing hidden protein family connections from the entire sequence tree | Zendy

Yaniv Loewenstein | Zendy; Michal Linial | Zendy

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Connect the dots: exposing hidden protein family connections from the entire sequence tree

Author(s) -

Yaniv Loewenstein,

Michal Linial

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn301

Subject(s) - protein family , phylogenetic tree , tree (set theory) , computational biology , biology , cluster analysis , multiple sequence alignment , protein superfamily , tracing , inference , family tree , phylogenetics , sequence alignment , protein sequencing , evolutionary biology , genetics , computer science , peptide sequence , artificial intelligence , gene , genealogy , history , mathematical analysis , mathematics , operating system

Mapping of remote evolutionary links is a classic computational problem of much interest. Relating protein families allows for functional and structural inference on uncharacterized families. Since sequences have diverged beyond reliable alignment, these are too remote to identify by conventional methods.

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