Open AccessPhosphoPOINT: a comprehensive human kinase interactome and phospho-protein database
Author(s) -
Chia-Ying Yang,
ChaoHui Chang,
Ya-Ling Yu,
Tsu-Chun Emma Lin,
ShengAn Lee,
ChuehChuan Yen,
JinnMoon Yang,
Jin-Mei Lai,
YiRen Hong,
Tzu-Ling Tseng,
KunMao Chao,
ChiYing F. Huang
Publication year - 2008
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btn297
Subject(s) - interactome , kinase , map2k7 , phosphorylation , c raf , biology , phosphoprotein , computational biology , biochemistry , protein kinase a , microbiology and biotechnology , cyclin dependent kinase 2 , gene
To fully understand how a protein kinase regulates biological processes, it is imperative to first identify its substrate(s) and interacting protein(s). However, of the 518 known human serine/threonine/tyrosine kinases, 35% of these have known substrates, while 14% of the kinases have identified substrate recognition motifs. In contrast, 85% of the kinases have protein-protein interaction (PPI) datasets, raising the possibility that we might reveal potential kinase-substrate pairs from these PPIs.
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