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Computing chemical organizations in biological networks
Author(s) -
Florian Centler,
Christoph Kaleta,
Pietro Speroni di Fenizio,
Peter Dittrich
Publication year - 2008
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btn228
Subject(s) - sbml , hierarchy , computer science , heuristics , theoretical computer science , biological network , systems biology , distributed computing , xml , markup language , bioinformatics , biology , economics , market economy , operating system
Novel techniques are required to analyze computational models of intracellular processes as they increase steadily in size and complexity. The theory of chemical organizations has recently been introduced as such a technique that links the topology of biochemical reaction network models to their dynamical repertoire. The network is decomposed into algebraically closed and self-maintaining subnetworks called organizations. They form a hierarchy representing all feasible system states including all steady states.

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