A support vector machine model for the prediction of proteotypic peptides for accurate mass and time proteomics
Author(s) -
BobbieJo WebbRobertson,
William R. Can,
Christopher Oehmen,
Anuj Shah,
Vidhya Gurumoorthi,
Mary Lipton,
Katrina M. Waters
Publication year - 2008
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btn218
Subject(s) - support vector machine , computer science , mass spectrometry , software , tandem mass spectrometry , shewanella oneidensis , computational biology , data mining , proteomics , artificial intelligence , chemistry , chromatography , biology , biochemistry , gene , programming language , bacteria , genetics
The standard approach to identifying peptides based on accurate mass and elution time (AMT) compares profiles obtained from a high resolution mass spectrometer to a database of peptides previously identified from tandem mass spectrometry (MS/MS) studies. It would be advantageous, with respect to both accuracy and cost, to only search for those peptides that are detectable by MS (proteotypic).
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