nuScore: a web-interface for nucleosome positioning predictions | Zendy

Michael Tolstorukov | Zendy; Vidhu Choudhary | Zendy; Wilma K. Olson | Zendy; Victor B. Zhurkin | Zendy; Peter J. Park | Zendy

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nuScore: a web-interface for nucleosome positioning predictions

Author(s) -

Michael Tolstorukov,

Vidhu Choudhary,

Wilma K. Olson,

Victor B. Zhurkin,

Peter J. Park

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn212

Subject(s) - nucleosome , interface (matter) , histone , computer science , sequence (biology) , web site , user interface , computational biology , threading (protein sequence) , dna , algorithm , data mining , computational science , bioinformatics , biology , genetics , the internet , world wide web , protein structure , parallel computing , programming language , biochemistry , bubble , maximum bubble pressure method

Sequence-directed mapping of nucleosome positions is of major biological interest. Here, we present a web-interface for estimation of the affinity of the histone core to DNA and prediction of nucleosome arrangement on a given sequence. Our approach is based on assessment of the energy cost of imposing the deformations required to wrap DNA around the histone surface. The interface allows the user to specify a number of options such as selecting from several structural templates for threading calculations and adding random sequences to the analysis.

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