Comparative conservation analysis of the human mitotic phosphoproteome | Zendy

Rainer Malik | Zendy; Erich A. Nigg | Zendy; Roman Körner | Zendy

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Comparative conservation analysis of the human mitotic phosphoproteome

Author(s) -

Rainer Malik,

Erich A. Nigg,

Roman Körner

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn197

Subject(s) - phosphorylation , biology , serine , threonine , conserved sequence , protein phosphorylation , computational biology , tyrosine phosphorylation , kinase , bioinformatics , genetics , protein kinase a , peptide sequence , gene

A key challenge in phosphoproteomic studies is to distinguish functionally relevant phosphorylation sites from potentially 'silent' phosphorylation. Considering that relevant phosphorylation sites are expected to be better conserved during evolution than overall Serine, Threonine and Tyrosine (S/ T/ Y) residues, we asked whether this can be directly demonstrated through statistic analysis, using a large experimental dataset.

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