BEN: a novel domain in chromatin factors and DNA viral proteins | Zendy

Saraswathi Abhiman | Zendy; Lakshminarayan M. Iyer | Zendy; L. Aravind | Zendy

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BEN: a novel domain in chromatin factors and DNA viral proteins

Author(s) -

Saraswathi Abhiman,

Lakshminarayan M. Iyer,

L. Aravind

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn007

Subject(s) - chromatin , biology , transcription (linguistics) , transcription factor , dna , genetics , gene isoform , dna binding domain , microbiology and biotechnology , computational biology , gene , linguistics , philosophy

We report a previously uncharacterized alpha-helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role for them in organization of viral DNA during replication or transcription.

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