Reconstructing ancestral genome content based on symmetrical best alignments and Dollo parsimony | Zendy

Onur Sakarya | Zendy; Kenneth S. Kosik | Zendy; Todd H. Oakley | Zendy

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Reconstructing ancestral genome content based on symmetrical best alignments and Dollo parsimony

Author(s) -

Onur Sakarya,

Kenneth S. Kosik,

Todd H. Oakley

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn005

Subject(s) - genome , gene duplication , biology , lineage (genetic) , gene , evolutionary biology , gene family , phylogenetics , segmental duplication , phylogenetic tree , genome evolution , computational biology , genetics

Gene duplications and losses (GDLs) are important events in genome evolution. They result in expansion or contraction of gene families, with a likely role in phenotypic evolution. As more genomes become available and their annotations are improved, software programs capable of rapidly and accurately identifying the content of ancestral genomes and the timings of GDLs become necessary to understand the unique evolution of each lineage.

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