Open AccessMultiple testing on the directed acyclic graph of gene ontology
Author(s) -
Jelle J. Goeman,
Ulrich Mansmann
Publication year - 2008
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btm628
Subject(s) - computer science , graph , focus (optics) , theoretical computer science , directed acyclic graph , ontology , data mining , algorithm , philosophy , physics , epistemology , optics
Current methods for multiplicity adjustment do not make use of the graph structure of Gene Ontology (GO) when testing for association of expression profiles of GO terms with a response variable.
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