Discovery of candidate KEN-box motifs using Cell Cycle keyword enrichment combined with native disorder prediction and motif conservation | Zendy

Sushama Michael | Zendy; Gilles Travé | Zendy; Chenna Ramu | Zendy; Claudia Chica | Zendy; Toby J. Gibson | Zendy

Open Access

Discovery of candidate KEN-box motifs using Cell Cycle keyword enrichment combined with native disorder prediction and motif conservation

Author(s) -

Sushama Michael,

Gilles Travé,

Chenna Ramu,

Claudia Chica,

Toby J. Gibson

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm624

Subject(s) - uniprot , biology , cell cycle , computational biology , motif (music) , mitosis , genetics , gene , physics , acoustics

KEN-box-mediated target selection is one of the mechanisms used in the proteasomal destruction of mitotic cell cycle proteins via the APC/C complex. While annotating the Eukaryotic Linear Motif resource (ELM, http://elm.eu.org/), we found that KEN motifs were significantly enriched in human protein entries with cell cycle keywords in the UniProt/Swiss-Prot database-implying that KEN-boxes might be more common than reported.

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