A new algorithm for cluster analysis of genomic methylation: the Helicobacter pylori case | Zendy

Filipa F. Vale | Zendy; Pedro Encarnação | Zendy; Jorge M. B. Vítor | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A new algorithm for cluster analysis of genomic methylation: the Helicobacter pylori case

Author(s) -

Filipa F. Vale,

Pedro Encarnação,

Jorge M. B. Vítor

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm621

Subject(s) - methyltransferase , dendrogram , methylation , restriction enzyme , cluster analysis , genome , helicobacter pylori , biology , computational biology , dna methylation , genetics , cluster (spacecraft) , computer science , dna , gene , artificial intelligence , medicine , computer network , genetic diversity , population , gene expression , environmental health

The genomic methylation analysis is useful to type bacteria that have a high number of expressed type II methyltransferases. Methyltransferases are usually committed to Restriction and Modification (R-M) systems, in which the restriction endonuclease imposes high pressure on the expression of the cognate methyltransferase that hinder R-M system loss. Conventional cluster methods do not reflect this tendency. An algorithm was developed for dendrogram construction reflecting the propensity for conservation of R-M Type II systems.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research