Precise score for the prediction of peptides cleaved by the proteasome | Zendy

Ido Ginodi | Zendy; Tal ViderShalit | Zendy; Lea Tsaban | Zendy; Yoram Louzoun | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Precise score for the prediction of peptides cleaved by the proteasome

Author(s) -

Ido Ginodi,

Tal ViderShalit,

Lea Tsaban,

Yoram Louzoun

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm616

Subject(s) - epitope , cleavage (geology) , proteasome , peptide , cytotoxic t cell , mhc class i , context (archaeology) , computational biology , chemistry , biology , in vitro , microbiology and biotechnology , biochemistry , antigen , immunology , paleontology , fracture (geology)

An 8-10mer can become a cytotoxic T lymphocyte epitope only if it is cleaved by the proteasome, transported by TAP and presented by MHC-I molecules. Thus most of the epitopes presented to cytotoxic T cells in the context of MHC-I molecules are products of intracellular proteasomal cleavage. These products are not random, as peptide production is a function of the precise sequence of the proteins processed by the proteasome.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research