Open AccessaffyGG: computational protocols for genetical genomics with Affymetrix arrays
Author(s) -
Rudi Alberts,
Gonzalo Vera,
Ritsert C. Jansen
Publication year - 2007
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btm614
Subject(s) - perl , biology , genomics , computational biology , software , genome , scripting language , genetics , functional genomics , computer science , gene , world wide web , operating system
Affymetrix arrays use multiple probes per gene to measure mRNA abundances. Standard software takes averages over probes. Important information may be lost if polymorphisms in the mRNA affect the hybridization of individual probes.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom