Model-based deconvolution of genome-wide DNA binding | Zendy

David J. Reiss | Zendy; Marc T. Facciotti | Zendy; Nitin S. Baliga | Zendy

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Model-based deconvolution of genome-wide DNA binding

Author(s) -

David J. Reiss,

Marc T. Facciotti,

Nitin S. Baliga

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm592

Subject(s) - tiling array , chromatin immunoprecipitation , dna microarray , computer science , computational biology , chip sequencing , deconvolution , dna binding site , biology , dna , chromatin , genetics , algorithm , gene , gene expression , promoter , nucleosome

Chromatin immunoprecipitation followed by hybridization to a genomic tiling microarray (ChIP-chip) is a routinely used protocol for localizing the genomic targets of DNA-binding proteins. The resolution to which binding sites in this assay can be identified is commonly considered to be limited by two factors: (1) the resolution at which the genomic targets are tiled in the microarray and (2) the large and variable lengths of the immunoprecipitated DNA fragments.

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