Putative promoter regions of miRNA genes involved in evolutionarily conserved regulatory systems among vertebrates | Zendy

Shuji Fujita | Zendy; Hideo Iba | Zendy

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Putative promoter regions of miRNA genes involved in evolutionarily conserved regulatory systems among vertebrates

Author(s) -

Shuji Fujita,

Hideo Iba

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm589

Subject(s) - biology , gene , promoter , microrna , transcription factor , genetics , regulation of gene expression , computational biology , conserved sequence , gene regulatory network , gene expression , regulatory sequence , base sequence

Just as transcription factors, miRNA genes modulate global patterns of gene expression during differentiation, metabolic activation, stimulus response and also carcinogenesis. However, little is currently known how the miRNA gene expression itself is regulated owing to lack of basic information of their gene structure. Global prediction of promoter regions of miRNA genes would allow us to explore the mechanisms underlying gene-regulatory mechanisms involving these miRNAs.

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