Fast and accurate identification of semi-tryptic peptides in shotgun proteomics | Zendy

Pedro Alves | Zendy; Randy J. Arnold | Zendy; David E. Clemmer | Zendy; Yixue Li | Zendy; James P. Reilly | Zendy; Quanhu Sheng | Zendy; Haixu Tang | Zendy; Zhiyin Xun | Zendy; Rong Zeng | Zendy; Predrag Radivojac | Zendy

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Fast and accurate identification of semi-tryptic peptides in shotgun proteomics

Author(s) -

Pedro Alves,

Randy J. Arnold,

David E. Clemmer,

Yixue Li,

James P. Reilly,

Quanhu Sheng,

Haixu Tang,

Zhiyin Xun,

Rong Zeng,

Predrag Radivojac

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm545

Subject(s) - shotgun proteomics , peptide , proteomics , bottom up proteomics , identification (biology) , shotgun , database search engine , peptide sequence , trypsin , computational biology , mass spectrometry , chromatography , chemistry , biology , computer science , tandem mass spectrometry , biochemistry , protein mass spectrometry , search engine , gene , information retrieval , botany , enzyme

One of the major problems in shotgun proteomics is the low peptide coverage when analyzing complex protein samples. Identifying more peptides, e.g. non-tryptic peptides, may increase the peptide coverage and improve protein identification and/or quantification that are based on the peptide identification results. Searching for all potential non-tryptic peptides is, however, time consuming for shotgun proteomics data from complex samples, and poses a challenge for a routine data analysis.

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