PfamAlyzer: domain-centric homology search | Zendy

Volker Hollich | Zendy; Erik L. L. Sonnhammer | Zendy

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PfamAlyzer: domain-centric homology search

Author(s) -

Volker Hollich,

Erik L. L. Sonnhammer

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm521

Subject(s) - homology (biology) , computational biology , computer science , domain (mathematical analysis) , biology , genetics , mathematics , gene , mathematical analysis

PfamAlyzer is a Java applet that enables exploration of Pfam domain architectures using a user-friendly graphical interface. It can search the UniProt protein database for a domain pattern. Domain patterns similar to the query are presented graphically by PfamAlyzer either in a ranked list or pinned to the tree of life. Such domain-centric homology search can assist identification of distant homologs with shared domain architecture.

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