NAPROC-13: a database for the dereplication of natural product mixtures in bioassay-guided protocols | Zendy

José Luis LópezPérez | Zendy; Roberto Therón | Zendy; Esther del Olmo | Zendy; David Díaz | Zendy

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NAPROC-13: a database for the dereplication of natural product mixtures in bioassay-guided protocols

Author(s) -

José Luis LópezPérez,

Roberto Therón,

Esther del Olmo,

David Díaz

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm516

Subject(s) - natural product , bottleneck , identification (biology) , bioassay , drug discovery , fractionation , component (thermodynamics) , database , biochemical engineering , process (computing) , isolation (microbiology) , combinatorial chemistry , computational biology , computer science , chemistry , biology , chromatography , bioinformatics , organic chemistry , engineering , ecology , embedded system , thermodynamics , operating system , physics

Although natural products represent a reservoir of molecular diversity, the process of isolating and identifying active compounds is a bottleneck in drug discovery programs. The rapid isolation and identification of the bioactive component(s) of natural product mixtures during the bioassay-guided fractionation have become crucial factors in the competition with chemical compound libraries and combinatorial synthetic efforts. In this respect, the use of spectral databases in identification processes is indispensable.

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