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MDQC: a new quality assessment method for microarrays based on quality control reports
Author(s) -
Gabriela V. Cohen Freue,
Zsuzsanna Hollander,
Enqing Shen,
Ruben H. Zamar,
Robert Balshaw,
Andreas Scherer,
Bruce M. McManus,
Paul Keown,
W. Robert McMaster,
Raymond T. Ng
Publication year - 2007
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btm487
Subject(s) - mahalanobis distance , computer science , quality (philosophy) , data mining , bioconductor , outlier , quality assurance , data quality , process (computing) , multivariate statistics , control (management) , quality score , artificial intelligence , metric (unit) , machine learning , engineering , philosophy , biochemistry , chemistry , external quality assessment , operations management , epistemology , gene , operating system
The process of producing microarray data involves multiple steps, some of which may suffer from technical problems and seriously damage the quality of the data. Thus, it is essential to identify those arrays with low quality. This article addresses two questions: (1) how to assess the quality of a microarray dataset using the measures provided in quality control (QC) reports; (2) how to identify possible sources of the quality problems.

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