IGG: A tool to integrate GeneChips for genetic studies | Zendy

Miaoxin Li | Zendy; Lei Jiang | Zendy; SL Ho | Zendy; YouQiang Song | Zendy; Pak C. Sham | Zendy

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IGG: A tool to integrate GeneChips for genetic studies

Author(s) -

Miaoxin Li,

Lei Jiang,

SL Ho,

YouQiang Song,

Pak C. Sham

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm458

Subject(s) - international hapmap project , computer science , genotyping , linkage (software) , genotype , data mining , biology , genetics , gene

To facilitate genetic studies using high-throughput genotyping technologies, we have developed an open source tool to integrate genotype data across the Affymetrix and Illumina platforms. It can efficiently integrate a large amount of data from various GeneChips, add genotypes of the HapMap Project into a specific project, flexibly trim and export the integrated data with different formats of popular genetic analysis tools, and highly control the quality of genotype data. Furthermore, this tool has sufficiently simplified its usage through its user-friendly graphic interface and is independent of third-party databases. IGG has successfully been applied to a genome-wide linkage scan in a Charcot-Marie-Tooth disease pedigree by integrating three types of GeneChips and HapMap project genotypes.

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