Exploiting sample variability to enhance multivariate analysis of microarray data
Author(s) -
Carla S. MöllerLevet,
Catharine West,
Crispin Miller
Publication year - 2007
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btm441
Subject(s) - data mining , computer science , pairwise comparison , sample (material) , microarray analysis techniques , gene chip analysis , multivariate statistics , correlation , exploit , dna microarray , machine learning , artificial intelligence , gene expression , mathematics , gene , biology , genetics , chemistry , geometry , computer security , chromatography
Biological and technical variability is intrinsic in any microarray experiment. While most approaches aim to account for this variability, they do not actively exploit it. Here, we consider a novel approach that uses the variability between arrays to provide an extra source of information that can enhance gene expression analyses.
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