Modular decomposition of metabolic reaction networks based on flux analysis and pathway projection | Zendy

Jeongah Yoon | Zendy; Yaguang Si | Zendy; Ryan P. Nolan | Zendy; Kyongbum Lee | Zendy

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Modular decomposition of metabolic reaction networks based on flux analysis and pathway projection

Author(s) -

Jeongah Yoon,

Yaguang Si,

Ryan P. Nolan,

Kyongbum Lee

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm374

Subject(s) - metabolic network , metabolic flux analysis , modularity (biology) , transamination , modular design , flux (metallurgy) , adipocyte , computer science , computational biology , flexibility (engineering) , biology , functional decomposition , metabolic pathway , decomposition , biological system , bioinformatics , metabolism , mathematics , chemistry , adipose tissue , biochemistry , genetics , ecology , statistics , organic chemistry , machine learning , enzyme , operating system

The rational decomposition of biochemical networks into sub-structures has emerged as a useful approach to study the design of these complex systems. A biochemical network is characterized by an inhomogeneous connectivity distribution, which gives rise to several organizational features, including modularity. To what extent the connectivity-based modules reflect the functional organization of the network remains to be further explored. In this work, we examine the influence of physiological perturbations on the modular organization of cellular metabolism.

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