RefPlus: an R package extending the RMA Algorithm | Zendy

Chris Harbron | Zendy; KaiMing Chang | Zendy; Marie C. South | Zendy

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RefPlus: an R package extending the RMA Algorithm

Author(s) -

Chris Harbron,

KaiMing Chang,

Marie C. South

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm357

Subject(s) - bioconductor , computer science , r package , set (abstract data type) , extrapolation , documentation , software , dglap , data mining , process (computing) , dna microarray , algorithm , data set , software package , programming language , mathematics , artificial intelligence , biology , statistics , gene expression , biochemistry , physics , particle physics , hadron , gene , parton

RMA has become a widely used methodology to pre-process Affymetrix gene expression microarrays. A limitation of RMA is that the calculated probeset intensities change when a set of microarrays is re-pre-processed after the inclusion of additional microarrays into the analysis set. Here we report the availability of the RefPlus package containing functions to perform the Extrapolation Strategy and Extrapolation Averaging algorithms which address these issues.

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