Eu.Gene Analyzer a tool for integrating gene expression data with pathway databases
Author(s) -
Duccio Cavalieri,
Cinzia Castagnini,
Simona Toti,
Karolina Maciag,
Thomas Kelder,
Luca Gambineri,
Samuele Angioli,
Piero Dolara
Publication year - 2007
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btm333
Subject(s) - java , computer science , context (archaeology) , graphical user interface , suite , set (abstract data type) , database , software , variety (cybernetics) , download , data mining , programming language , world wide web , artificial intelligence , biology , history , paleontology , archaeology
Eu.Gene Analyzer is an easy-to-use, stand-alone application that allows rapid and powerful microarray data analysis in the context of biological pathways. Its intuitive graphical user interface makes it an easy and flexible tool, even for the first-time user. Eu.Gene supports a variety of array platforms, organisms and pathway ontologies, transparently deals with multiple nomenclature systems and seamlessly integrates data from different sources. Two different statistical methods, the Fisher Exact Test and the Gene Set Enrichment Analysis (GSEA), are implemented to identify biological pathways transcriptionally affected under experimental conditions. A suite of tools is offered to define, visualize and share custom non-redundant pathway sets. In conclusion, Eu.Gene Analyzer is a new software application that takes advantage of information from multiple pathway databases to build a comprehensive interpretation of experimental results in a simple, intuitive environment.
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