Constraint-based functional similarity of metabolic genes: going beyond network topology | Zendy

Oleg Rokhlenko | Zendy; Tomer Shlomi | Zendy; Roded Sharan | Zendy; Eytan Ruppin | Zendy; Ron Y. Pinter | Zendy

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Constraint-based functional similarity of metabolic genes: going beyond network topology

Author(s) -

Oleg Rokhlenko,

Tomer Shlomi,

Roded Sharan,

Eytan Ruppin,

Ron Y. Pinter

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm319

Subject(s) - in silico , metabolic network , constraint (computer aided design) , gene knockout , gene , computational biology , gene regulatory network , similarity (geometry) , computer science , gene ontology , biology , data mining , genetics , artificial intelligence , mathematics , gene expression , geometry , image (mathematics)

Several recent studies attempted to establish measures for the similarity between genes that are based on the topological properties of metabolic networks. However, these approaches offer only a static description of the properties of interest and offer moderate (albeit significant) correlations with pertinent experimental data.

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