HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies | Zendy

Jason M. Laramie | Zendy; Jemma B. Wilk | Zendy; Anita L. DeStefano | Zendy; Richard H. Myers | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies

Author(s) -

Jason M. Laramie,

Jemma B. Wilk,

Anita L. DeStefano,

Richard H. Myers

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm316

Subject(s) - haplotype , single nucleotide polymorphism , construct (python library) , genetics , snp , haplotype estimation , biology , genetic association , computer science , computational biology , algorithm , gene , genotype , programming language

We have created a program that searches densely genotyped regions for associated non-contiguous haplotypes using a standard family based haplotype association test. This program was designed to expand upon the 'sliding window' methodologies commonly used for haplotype construction by allowing the association of subsets of single nucleotide polymorphisms (SNPs) to drive the construction of the haplotype. This strategy permits HaploBuild to construct more biologically relevant haplotypes that are not constrained by arbitrary length and contiguous orientation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research