dPattern: transcription factor binding site (TFBS) discovery in human genome using a discriminative pattern analysis | Zendy

Seung-Hee Bae | Zendy; Haixu Tang | Zendy; Jing Qin Wu | Zendy; Jun Xie | Zendy; Sun Kim | Zendy

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dPattern: transcription factor binding site (TFBS) discovery in human genome using a discriminative pattern analysis

Author(s) -

Seung-Hee Bae,

Haixu Tang,

Jing Qin Wu,

Jun Xie,

Sun Kim

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm288

Subject(s) - dna binding site , false positive paradox , promoter , discriminative model , binding site , computational biology , transcription factor , genome , genetics , gene , biology , data mining , computer science , gene expression , artificial intelligence

Transcription factor binding sites (TFBSs) are typically short in length, thus search with a profile model from known TFBSs produces many false positives. When combined with additional information, gene expression data in this article, sensitivity and specificity of TFBS search can be improved significantly.

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