Short oligonucleotide probes containing G-stacks display abnormal binding affinity on Affymetrix microarrays | Zendy

Chunlei Wu | Zendy; Haitao Zhao | Zendy; Keith Baggerly | Zendy; R Carta | Zendy; Li Zhang | Zendy

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Short oligonucleotide probes containing G-stacks display abnormal binding affinity on Affymetrix microarrays

Author(s) -

Chunlei Wu,

Haitao Zhao,

Keith Baggerly,

R Carta,

Li Zhang

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm271

Subject(s) - oligonucleotide , dna microarray , computational biology , microarray , microbiology and biotechnology , biology , chemistry , genetics , dna , gene , gene expression

In microarray experiments, probe design is critical to the specific and accurate measurement of target concentrations. Current designs select suitable probes through in silico scanning of transcriptome/genome based on first principles. However, due to lack of tools, the observed microarray data have not been used to assess the performance of individual probes to provide feedback to improve future designs.

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