The Cytochrome P450 Engineering Database: a navigation and prediction tool for the cytochrome P450 protein family | Zendy

Markus Fischer | Zendy; Michael Knoll | Zendy; Demet Sirim | Zendy; Florian Wagner | Zendy; Sonja Funke | Zendy; Juergen Pleiss | Zendy

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The Cytochrome P450 Engineering Database: a navigation and prediction tool for the cytochrome P450 protein family

Author(s) -

Markus Fischer,

Michael Knoll,

Demet Sirim,

Florian Wagner,

Sonja Funke,

Juergen Pleiss

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm268

Subject(s) - phylogenetic tree , monooxygenase , cytochrome p450 , computational biology , biology , cytochrome , hidden markov model , sequence database , sequence alignment , protein family , database , bioinformatics , genetics , computer science , peptide sequence , gene , artificial intelligence , biochemistry , enzyme

The Cytochrome P450 Engineering Database (CYPED) has been designed to serve as a tool for a comprehensive and systematic comparison of protein sequences and structures within the vast and diverse family of cytochrome P450 monooxygenases (CYPs). The CYPED currently integrates sequence and structure data of 3911 and 25 proteins, respectively. Proteins are grouped into homologous families and superfamilies according to Nelson's classification. Nonclassified CYP sequences are assigned by similarity. Functionally relevant residues are annotated. The web accessible version contains multisequence alignments, phylogenetic trees and HMM profiles. The CYPED is regularly updated and supplies all data for download. Thus, it provides a valuable data source for phylogenetic analysis, investigation of sequence-function relationships and the design of CYPs with improved biochemical properties.

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