Error detection in SNP data by considering the likelihood of recombinational history implied by three-site combinations | Zendy

Donna Toleno | Zendy; Peter L. Morrell | Zendy; Michael T. Clegg | Zendy

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Error detection in SNP data by considering the likelihood of recombinational history implied by three-site combinations

Author(s) -

Donna Toleno,

Peter L. Morrell,

Michael T. Clegg

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm260

Subject(s) - perl , coalescent theory , haplotype , single nucleotide polymorphism , genotyping , snp , computer science , genetics , snp genotyping , computational biology , biology , data mining , gene , allele , genotype , phylogenetics , world wide web

Errors in nucleotide sequence and SNP genotyping data are problematic when inferring haplotypes. Previously published methods for error detection in haplotype data make use of pedigree information; however, for many samples, individuals are not related by pedigree. This article describes a method for detecting errors in haplotypes by considering the recombinational history implied by the patterns of variation, three SNPs at a time.

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