ChromatinDB: a database of genome-wide histone modification patterns forSaccharomyces cerevisiae | Zendy

Timothy O’Connor | Zendy; John J. Wyrick | Zendy

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ChromatinDB: a database of genome-wide histone modification patterns forSaccharomyces cerevisiae

Author(s) -

Timothy O’Connor,

John J. Wyrick

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm236

Subject(s) - chromatin immunoprecipitation , histone , saccharomyces cerevisiae , chip on chip , chromatin , computational biology , genome browser , genome , dna microarray , biology , genetics , yeast , gene , genomics , gene expression , histone h2a , promoter

Covalent modifications to histone proteins play a critical role in regulating gene transcription. Previous studies have used chromatin immunoprecipitation (ChIP) based microarray assays to profile genomic regions that are enriched or depleted for a particular histone modification. Such studies have been conducted extensively in the yeast Saccharomyces cerevisiae, but currently no comprehensive data repositories or analysis tools are available for these data sets. For this reason, we have developed the ChromatinDB database, which contains genome-wide ChIP data for 22 different histones or histone modifications in S. cerevisiae. ChromatinDB provides novel tools to facilitate the visualization and statistical analysis of chromatin features for user-selected gene sets.

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