Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics | Zendy

Khuloud Jaqaman | Zendy; Jonas F. Dorn | Zendy; Eugenio Marco | Zendy; Peter K. Sorger | Zendy; Gaudenz Danuser | Zendy

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Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics

Author(s) -

Khuloud Jaqaman,

Jonas F. Dorn,

Eugenio Marco,

Peter K. Sorger,

Gaudenz Danuser

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm230

Subject(s) - kinetochore , chromosome segregation , spindle apparatus , biology , cluster analysis , chromosome , mitosis , microtubule , computational biology , genetics , cell division , computer science , gene , cell , artificial intelligence

Kinetochores are multiprotein complexes which mediate chromosome attachment to microtubules (MTs) of the mitotic spindle. They regulate MT dynamics during chromosome segregation. Our goal is to identify groups of kinetochore proteins with similar effects on MT dynamics, revealing pathways through which kinetochore proteins transform chemical and mechanical input signals into cues of MT regulation.

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