Homology search for genes | Zendy

Xuefeng Cui | Zendy; Tomáš Vinař | Zendy; Broňa Brejová | Zendy; Dennis Shasha | Zendy; Ming Li | Zendy

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Homology search for genes

Author(s) -

Xuefeng Cui,

Tomáš Vinař,

Broňa Brejová,

Dennis Shasha,

Ming Li

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm225

Subject(s) - gene , homology (biology) , gene prediction , genome , annotation , gene annotation , exon , genetics , computational biology , biology , computer science , human genome , ensembl , genomics

Life science researchers often require an exhaustive list of protein coding genes similar to a given query gene. To find such genes, homology search tools, such as BLAST or PatternHunter, return a set of high-scoring pairs (HSPs). These HSPs then need to be correlated with existing sequence annotations, or assembled manually into putative gene structures. This process is error-prone and labor-intensive, especially in genomes without reliable gene annotation.

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