From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis | Zendy

Suman Sundaresh | Zendy; Arlo Randall | Zendy; Berkay Unal | Zendy; Jeannine M. Petersen | Zendy; John T. Belisle | Zendy; M. Gill Hartley | Zendy; Melanie Duffield | Zendy; Richard W. Titball | Zendy; D. Huw Davies | Zendy; Philip L. Felgner | Zendy; Pierre Baldi | Zendy

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From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis

Author(s) -

Suman Sundaresh,

Arlo Randall,

Berkay Unal,

Jeannine M. Petersen,

John T. Belisle,

M. Gill Hartley,

Melanie Duffield,

Richard W. Titball,

D. Huw Davies,

Philip L. Felgner,

Pierre Baldi

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm207

Subject(s) - protein microarray , antigen , francisella tularensis , dna microarray , microarray , computational biology , biology , microarray analysis techniques , gene chip analysis , computer science , data mining , virulence , immunology , genetics , gene expression , gene

An important application of protein microarray data analysis is identifying a serodiagnostic antigen set that can reliably detect patterns and classify antigen expression profiles. This work addresses this problem using antibody responses to protein markers measured by a novel high-throughput microarray technology. The findings from this study have direct relevance to rapid, broad-based diagnostic and vaccine development.

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