Kinetics analysis methods for approximate folding landscapes
Author(s) -
Lydia Tapia,
Xinyu Tang,
Shawna Thomas,
Nancy M. Amato
Publication year - 2007
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btm199
Subject(s) - folding (dsp implementation) , protein folding , population , monte carlo method , biological system , kinetics , statistical physics , downhill folding , master equation , helix (gastropod) , energy landscape , chemistry , computer science , phi value analysis , physics , mathematics , thermodynamics , biology , statistics , ecology , biochemistry , demography , quantum mechanics , sociology , snail , electrical engineering , quantum , engineering
Protein motions play an essential role in many biochemical processes. Lab studies often quantify these motions in terms of their kinetics such as the speed at which a protein folds or the population of certain interesting states like the native state. Kinetic metrics give quantifiable measurements of the folding process that can be compared across a group of proteins such as a wild-type protein and its mutants.
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