Genomix: a method for combining gene-finders' predictions, which uses evolutionary conservation of sequence and intron–exon structure | Zendy

Avril Coghlan | Zendy; Richard Durbin | Zendy

Open Access

Genomix: a method for combining gene-finders' predictions, which uses evolutionary conservation of sequence and intron–exon structure

Author(s) -

Avril Coghlan,

Richard Durbin

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm133

Subject(s) - exon , gene , sanger sequencing , biology , genetics , intron , genome , computational biology , gene prediction , caenorhabditis , sequence (biology) , dna sequencing

Correct gene predictions are crucial for most analyses of genomes. However, in the absence of transcript data, gene prediction is still challenging. One way to improve gene-finding accuracy in such genomes is to combine the exons predicted by several gene-finders, so that gene-finders that make uncorrelated errors can correct each other.

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