Open AccessModeling sequence–sequence interactions for drug response
Author(s) -
Min Lin,
Hongying Li,
Wei Hou,
Julie A. Johnson,
Rongling Wu
Publication year - 2007
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btm110
Subject(s) - haplotype , pharmacogenomics , pharmacogenetics , computational biology , biology , drug response , genetics , bioinformatics , drug , gene , pharmacology , genotype
Genetic interactions or epistasis may play an important role in the genetic etiology of drug response. With the availability of large-scale, high-density single nucleotide polymorphism markers, a great challenge is how to associate haplotype structures and complex drug response through its underlying pharmacodynamic mechanisms.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom