The impact of function perturbations in Boolean networks | Zendy

Yufei Xiao | Zendy; Edward R. Dougherty | Zendy

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The impact of function perturbations in Boolean networks

Author(s) -

Yufei Xiao,

Edward R. Dougherty

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm093

Subject(s) - boolean network , attractor , biological network , robustness (evolution) , perturbation (astronomy) , computer science , gene regulatory network , network structure , network analysis , complex network , boolean function , network topology , topology (electrical circuits) , theoretical computer science , mathematics , algorithm , biology , computer network , physics , gene , mathematical analysis , gene expression , combinatorics , quantum mechanics , biochemistry , world wide web

A network is said to be robust relative to a certain network characteristic if a small change in network structure does not significantly affect the characteristic. From the perspective of network stability, robustness is desirable; however, from the perspective of intervention to exert influence on network behavior, it is undesirable. For Boolean networks, there are two fundamental types of robustness. One type pertains to perturbing the state of the network and the other to perturbing the rule-based structure.

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