Local structural disorder imparts plasticity on linear motifs | Zendy

Mónika Fuxreiter | Zendy; Péter Tompa | Zendy; István Simon | Zendy

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Local structural disorder imparts plasticity on linear motifs

Author(s) -

Mónika Fuxreiter,

Péter Tompa,

István Simon

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btm035

Subject(s) - generality , structural motif , motif (music) , phosphorylation , computational biology , computer science , exponential growth , biology , biophysics , microbiology and biotechnology , physics , biochemistry , psychology , acoustics , psychotherapist , quantum mechanics

The dynamic nature of protein interaction networks requires fast and transient molecular switches. The underlying recognition motifs (linear motifs, LMs) are usually short and evolutionarily variable segments, which in several cases, such as phosphorylation sites or SH3-binding regions, fall into locally disordered regions. We probed the generality of this phenomenon by predicting the intrinsic disorder of all LM-containing proteins enlisted in the Eukaryotic Linear Motif (ELM) database.

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