LFM-Pro: a tool for detecting significant local structural sites in proteins
Author(s) -
Ahmet Saçan,
Özgür Öztürk,
Hakan Ferhatosmanoğlu,
Yusu Wang
Publication year - 2007
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btl685
Subject(s) - protein family , structural classification of proteins database , set (abstract data type) , identification (biology) , computational biology , computer science , feature (linguistics) , artificial intelligence , pattern recognition (psychology) , protein structure , data mining , biology , genetics , biochemistry , linguistics , botany , philosophy , gene , programming language
The rapidly growing protein structure repositories have opened up new opportunities for discovery and analysis of functional and evolutionary relationships among proteins. Detecting conserved structural sites that are unique to a protein family is of great value in identification of functionally important atoms and residues. Currently available methods are computationally expensive and fail to detect biologically significant local features.
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