LdCompare: rapid computation of single- and multiple-markerr2 and genetic coverage | Zendy

Ke Hao | Zendy; X. Di | Zendy; Simon Cawley | Zendy

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LdCompare: rapid computation of single- and multiple-markerr2 and genetic coverage

Author(s) -

Ke Hao,

X. Di,

Simon Cawley

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl574

Subject(s) - computation , computer science , genetic marker , genetic algorithm , computational biology , genetics , algorithm , biology , machine learning , gene

The scale of genetic-variation datasets has increased enormously and the linkage equilibrium (LD) structure of these polymorphisms, particularly in whole-genome association studies, is of great interest. The significant computational complexity of calculating single- and multiple-marker correlations at a genome-wide scale remains challenging. We have developed a program that efficiently characterizes whole-genome LD structure on large number of SNPs in terms of single- and multiple-marker correlations.

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