DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold | Zendy

Mensur Dlakić | Zendy

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DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold

Author(s) -

Mensur Dlakić

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl468

Subject(s) - dicer , argonaute , rna interference , biology , rna induced silencing complex , rna silencing , rna , gene silencing , ribonuclease iii , microbiology and biotechnology , computational biology , genetics , gene

Two RNases, Dicer and Argonaute, are at the heart of the RNA interference (RNAi) molecular machinery responsible for gene silencing. Both RNases contain multiple domains, most of which have been characterized or have functions that can be predicted based on sequence comparisons. However, Dicers of higher eukaryotes contain the domain known as DUF283 which at present has no assigned role. Using sensitive profile-profile comparisons, we detected a divergent double-stranded RNA-binding domain coinciding with the DUF283 of Dicer. This finding has potential implications regarding the mechanistic role of Dicer in RNAi.

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