Survival analysis of longitudinal microarrays
Author(s) -
Natasa Rajicic,
Dianne M. Finkelstein,
David Schoenfeld
Publication year - 2006
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btl450
Subject(s) - dna microarray , significance analysis of microarrays , event (particle physics) , survival analysis , computational biology , gene expression profiling , time point , construct (python library) , gene expression , expression (computer science) , false discovery rate , longitudinal data , gene , biology , bioinformatics , data mining , computer science , genetics , medicine , philosophy , physics , quantum mechanics , programming language , aesthetics
The development of methods for linking gene expressions to various clinical and phenotypic characteristics is an active area of genomic research. Scientists hope that such analysis may, for example, describe relationships between gene function and clinical events such as death or recovery. Methods are available for relating gene expression to measurements that are categorized or continuous, but there is less work in relating expressions to an observed event time such as time to death, response or relapse. When gene expressions are measured over time, there are methods for differentiating temporal patterns. However, methods have not yet been proposed for the survival analysis of longitudinally collected microarrays.
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