Detecting functional modules in the yeast protein–protein interaction network | Zendy

Jingchun Chen | Zendy; Bo Yuan | Zendy

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Detecting functional modules in the yeast protein–protein interaction network

Author(s) -

Jingchun Chen,

Bo Yuan

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl370

Subject(s) - betweenness centrality , computer science , computational biology , interaction network , identification (biology) , partition (number theory) , annotation , graph , protein–protein interaction , functional genomics , proteome , theoretical computer science , biology , artificial intelligence , gene , bioinformatics , genomics , genome , genetics , mathematics , centrality , botany , combinatorics

Identification of functional modules in protein interaction networks is a first step in understanding the organization and dynamics of cell functions. To ensure that the identified modules are biologically meaningful, network-partitioning algorithms should take into account not only topological features but also functional relationships, and identified modules should be rigorously validated.

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