A lock-and-key model for protein–protein interactions | Zendy

Julie Morrison | Zendy; Rainer Breitling | Zendy; Desmond J. Higham | Zendy; David Gilbert | Zendy

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A lock-and-key model for protein–protein interactions

Author(s) -

Julie Morrison,

Rainer Breitling,

Desmond J. Higham,

David Gilbert

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl338

Subject(s) - bipartite graph , computer science , interactome , protein interaction networks , spurious relationship , protein–protein interaction , key (lock) , theoretical computer science , interaction information , interaction network , computational biology , graph , data mining , machine learning , biology , genetics , mathematics , gene , statistics , computer security

Protein-protein interaction networks are one of the major post-genomic data sources available to molecular biologists. They provide a comprehensive view of the global interaction structure of an organism's proteome, as well as detailed information on specific interactions. Here we suggest a physical model of protein interactions that can be used to extract additional information at an intermediate level: It enables us to identify proteins which share biological interaction motifs, and also to identify potentially missing or spurious interactions.

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