Robust estimation of the false discovery rate
Author(s) -
Stanley Pounds,
Cheng Cheng
Publication year - 2006
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btl328
Subject(s) - false discovery rate , computer science , multiple comparisons problem , simple (philosophy) , series (stratigraphy) , algorithm , estimation , data mining , mathematics , statistics , paleontology , biochemistry , chemistry , philosophy , management , epistemology , biology , economics , gene
Presently available methods that use p-values to estimate or control the false discovery rate (FDR) implicitly assume that p-values are continuously distributed and based on two-sided tests. Therefore, it is difficult to reliably estimate the FDR when p-values are discrete or based on one-sided tests.
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