Identification of conserved protein complexes based on a model of protein network evolution | Zendy

Eitan Hirsh | Zendy; Roded Sharan | Zendy

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Identification of conserved protein complexes based on a model of protein network evolution

Author(s) -

Eitan Hirsh,

Roded Sharan

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl295

Subject(s) - computational biology , biology , yeast , conserved sequence , identification (biology) , probabilistic logic , gene duplication , protein–protein interaction , gene , model organism , biological network , protein family , statistical model , genetics , computer science , machine learning , peptide sequence , artificial intelligence , ecology

Data on protein-protein interactions (PPIs) are increasing exponentially. To date, large-scale protein interaction networks are available for human and most model species. The arising challenge is to organize these networks into models of cellular machinery. As in other biological domains, a comparative approach provides a powerful basis for addressing this challenge.

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