Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family | Zendy

Rafaël Najmanovich | Zendy; Abdellah AllaliHassani | Zendy; Richard J. Morris | Zendy; Ludmila Dombrovsky | Zendy; Patricia W. Pan | Zendy; Masoud Vedadi | Zendy; A.N. Plotnikov | Zendy; A.M. Edwards | Zendy; C.H. Arrowsmith | Zendy; Janet M. Thornton | Zendy

Open Access

Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family

Author(s) -

Rafaël Najmanovich,

Abdellah AllaliHassani,

Richard J. Morris,

Ludmila Dombrovsky,

Patricia W. Pan,

Masoud Vedadi,

A.N. Plotnikov,

A.M. Edwards,

C.H. Arrowsmith,

Janet M. Thornton

Publication year - 2007

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl292

Subject(s) - small molecule , structural similarity , binding site , similarity (geometry) , sulfotransferase , molecule , plasma protein binding , computational biology , function (biology) , chemistry , biology , biochemistry , genetics , sulfation , computer science , organic chemistry , artificial intelligence , image (mathematics)

In the present work we combine computational analysis and experimental data to explore the extent to which binding site similarities between members of the human cytosolic sulfotransferase family correlate with small-molecule binding profiles. Conversely, from a small-molecule point of view, we explore the extent to which structural similarities between small molecules correlate to protein binding profiles.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research