Finding novel genes in bacterial communities isolated from the environment | Zendy

Lutz Krause | Zendy; Naryttza N. Diaz | Zendy; Daniela Bartels | Zendy; Robert A. Edwards | Zendy; Alfred Pühler | Zendy; Forest Rohwer | Zendy; Folker Meyer | Zendy; Jens Stoye | Zendy

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Finding novel genes in bacterial communities isolated from the environment

Author(s) -

Lutz Krause,

Naryttza N. Diaz,

Daniela Bartels,

Robert A. Edwards,

Alfred Pühler,

Forest Rohwer,

Folker Meyer,

Jens Stoye

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl247

Subject(s) - contig , metagenomics , gene , exploit , frame (networking) , computer science , computational biology , gene prediction , sample (material) , biology , data mining , genetics , genome , telecommunications , chemistry , computer security , chromatography

Novel sequencing techniques can give access to organisms that are difficult to cultivate using conventional methods. When applied to environmental samples, the data generated has some drawbacks, e.g. short length of assembled contigs, in-frame stop codons and frame shifts. Unfortunately, current gene finders cannot circumvent these difficulties. At the same time, the automated prediction of genes is a prerequisite for the increasing amount of genomic sequences to ensure progress in metagenomics.

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