Mutation parameters from DNA sequence data using graph theoretic measures on lineage trees | Zendy

Reuma MagoriCohen | Zendy; Yoram Louzoun | Zendy; Steven H. Kleinstein | Zendy

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Mutation parameters from DNA sequence data using graph theoretic measures on lineage trees

Author(s) -

Reuma MagoriCohen,

Yoram Louzoun,

Steven H. Kleinstein

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl239

Subject(s) - somatic hypermutation , biology , affinity maturation , mutation , phylogenetic tree , lineage (genetic) , genetics , computational biology , mutation rate , germline mutation , gene , b cell , antibody

B cells responding to antigenic stimulation can fine-tune their binding properties through a process of affinity maturation composed of somatic hypermutation, affinity-selection and clonal expansion. The mutation rate of the B cell receptor DNA sequence, and the effect of these mutations on affinity and specificity, are of critical importance for understanding immune and autoimmune processes. Unbiased estimates of these properties are currently lacking due to the short time-scales involved and the small numbers of sequences available.

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